The literal sense is of someone.
When addressing one's own family members or addressing or referring to someone else's family members, honorific forms are used.
Which titles are used depends on the particular licensing organization.
Usage in this respect has changed over time as well.
While some honorifics such as -san are very frequently used due to their gender neutrality and very simple definition of polite unfamiliarity, other honorifics such as -chan or -kun are more specific as to the context in which they must be used as well as the implications they give off when attached to a person's name.